InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF5

Summary

InnateDB Protein

IDBP-21486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF5

Protein Name

eukaryotic translation initiation factor 5

Synonyms

EIF-5; EIF-5A;

Species

Homo sapiens

Ensembl Protein

ENSP00000216554

InnateDB Gene

IDBG-21484 (EIF5)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0003924	GTPase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002735 Translation initiation factor IF2/IF5
IPR003307 W2 domain
IPR016024 Armadillo-type fold
IPR016189 Translation initiation factor IF2/IF5, N-terminal
IPR016190 Translation initiation factor IF2/IF5, zinc-binding

PFAM

PF01873
PF02020

PRINTS

PIRSF

SMART

SM00653
SM00515

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55010