Homo sapiens Gene: EIF5
Summary
InnateDB Gene IDBG-21484.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF5
Gene Name eukaryotic translation initiation factor 5
Synonyms EIF-5; EIF-5A;
Species Homo sapiens
Ensembl Gene ENSG00000100664
Encoded Proteins
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
eukaryotic translation initiation factor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103333544-103345025
Strand Forward strand
Band q32.32
Transcripts
ENST00000216554 ENSP00000216554
ENST00000392715 ENSP00000376477
ENST00000560877
ENST00000559249
ENST00000560338 ENSP00000453633
ENST00000560763 ENSP00000452636
ENST00000560200
ENST00000558316 ENSP00000453396
ENST00000558265 ENSP00000453856
ENST00000561325 ENSP00000452883
ENST00000559130 ENSP00000452615
ENST00000559532 ENSP00000453468
ENST00000558506 ENSP00000453743
ENST00000558551
ENST00000561439
ENST00000561023
ENST00000559923
ENST00000559011
ENST00000561380
ENST00000558800
ENST00000561406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Translation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Gene Expression pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
Regulation of eif2 [Biocarta view]
Eukaryotic protein translation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.433702 Hs.592633 Hs.593996 Hs.669983 Hs.718163
RefSeq NM_001969 NM_183004
HUGO
OMIM
CCDS CCDS9980
HPRD 03417
IMGT
EMBL
GenPept
RNA Seq Atlas