InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF5

Summary

InnateDB Gene

IDBG-21484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF5

Gene Name

eukaryotic translation initiation factor 5

Synonyms

EIF-5; EIF-5A

Species

Homo sapiens

Ensembl Gene

ENSG00000100664

Encoded Proteins

IDBP-21486

eukaryotic translation initiation factor 5

IDBP-245084

eukaryotic translation initiation factor 5

IDBP-595375

eukaryotic translation initiation factor 5

IDBP-593526

eukaryotic translation initiation factor 5

IDBP-601947

eukaryotic translation initiation factor 5

IDBP-591442

eukaryotic translation initiation factor 5

IDBP-589985

eukaryotic translation initiation factor 5

IDBP-598296

eukaryotic translation initiation factor 5

IDBP-595020

eukaryotic translation initiation factor 5

IDBP-600284

eukaryotic translation initiation factor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:103333544-103345025

Strand

Forward strand

Band

q32.32

Transcripts

ENST00000216554	ENSP00000216554
ENST00000392715	ENSP00000376477
ENST00000560877
ENST00000559249
ENST00000560338	ENSP00000453633
ENST00000560763	ENSP00000452636
ENST00000560200
ENST00000558316	ENSP00000453396
ENST00000558265	ENSP00000453856
ENST00000561325	ENSP00000452883
ENST00000559130	ENSP00000452615
ENST00000559532	ENSP00000453468
ENST00000558506	ENSP00000453743
ENST00000558551
ENST00000561439
ENST00000561023
ENST00000559923
ENST00000559011
ENST00000561380
ENST00000558800
ENST00000561406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0003924	GTPase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021282

View Gene Order

ENSBTAG00000016282

Not yet available

Pathways

NETPATH

REACTOME

REACT_2085

GTP hydrolysis and joining of the 60S ribosomal subunit pathway

REACT_931

Ribosomal scanning and start codon recognition pathway

REACT_2159

Eukaryotic Translation Initiation pathway

REACT_1014

Translation pathway

REACT_17015

Metabolism of proteins pathway

REACT_2099

Cap-dependent Translation Initiation pathway

REACT_71

Gene Expression pathway

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H0YK11 H0YK29 H0YM54 H0YMJ8

UniProt Splice Variant

Entrez Gene

1983

UniGene

Hs.433702 Hs.592633 Hs.593996 Hs.669983 Hs.718163

RefSeq

NM_001969 NM_183004

HUGO

HGNC:3299

OMIM

601710

CCDS

CCDS9980

HPRD

03417

IMGT

EMBL

AL138976

GenPept

RNA Seq Atlas

1983