InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLC1

Summary

InnateDB Protein

IDBP-21860.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLC1

Protein Name

kinesin light chain 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000341154

InnateDB Gene

IDBG-21848 (KLC1)

Protein Structure

UniProt Annotation

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Subcellular Localization

Cell projection, growth cone {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000305PubMed:14970196}.

Disease Associations

Tissue Specificity

Found in a variety of tissues. Mostly abundant in brain and spine. {ECO:0000269PubMed:14970196}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003777	microtubule motor activity
GO:0005515	protein binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0016032	viral process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0035617	stress granule disassembly

Cellular Component

GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR002151 Kinesin light chain
IPR013026 Tetratricopeptide repeat-containing domain
IPR015390 Rabaptin, GTPase-Rab5 binding domain
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF09311
PF13174
PF13176
PF13181

PRINTS

PR00381

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt