InnateDB Protein
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IDBP-21889.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LYPLA1
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Protein Name
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lysophospholipase I
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Synonyms
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APT-1; APT1; hAPT1; LPL-I; LPL1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344477
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InnateDB Gene
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IDBG-21885 (LYPLA1)
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Protein Structure
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Function |
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity. {ECO:0000269PubMed:20418879, ECO:0000269PubMed:22399288}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003140
Phospholipase/carboxylesterase/thioesterase
IPR013094
Alpha/beta hydrolase fold-3
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF02230
PF07859
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75608
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PhosphoSite |
PhosphoSite-O75608
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TrEMBL |
E5RGR0
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UniProt Splice Variant |
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Entrez Gene |
10434
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UniGene |
Hs.733073
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RefSeq |
NP_001266286
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HUGO |
HGNC:6737
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OMIM |
605599
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CCDS |
CCDS64899
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HPRD |
07063
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IMGT |
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EMBL |
AC100821
AF035293
AF077198
AF077199
AF081281
AF291053
BC008652
BC010397
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GenPept |
AAB88180
AAC31610
AAD26993
AAD26994
AAG10063
AAH08652
AAH10397
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