InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LYPLA1

Summary

InnateDB Gene

IDBG-21885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LYPLA1

Gene Name

lysophospholipase I

Synonyms

APT-1; APT1; hAPT1; LPL-I; LPL1

Species

Homo sapiens

Ensembl Gene

ENSG00000120992

Encoded Proteins

IDBP-21887

lysophospholipase I

IDBP-21889

lysophospholipase I

IDBP-479827

lysophospholipase I

IDBP-478326

lysophospholipase I

IDBP-477049

lysophospholipase I

IDBP-484398

lysophospholipase I

IDBP-808230

lysophospholipase I

IDBP-808232

lysophospholipase I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:54046367-54102017

Strand

Reverse strand

Band

q11.23

Transcripts

ENST00000316963	ENSP00000320043
ENST00000343231	ENSP00000344477
ENST00000519272
ENST00000520718
ENST00000518546	ENSP00000428729
ENST00000522007	ENSP00000427967
ENST00000519891
ENST00000521352	ENSP00000428306
ENST00000519926
ENST00000517297
ENST00000521898	ENSP00000430791
ENST00000520896
ENST00000521856
ENST00000618914	ENSP00000482430
ENST00000618741	ENSP00000484280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0008474	palmitoyl-(protein) hydrolase activity
GO:0016787	hydrolase activity

Biological Process

GO:0002084	protein depalmitoylation
GO:0006631	fatty acid metabolic process
GO:0008152	metabolic process
GO:0042997	negative regulation of Golgi to plasma membrane protein transport
GO:0044281	small molecule metabolic process
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025903

View Gene Order

ENSBTAG00000004243

Not yet available

Pathways

NETPATH

REACTOME

REACT_12477

eNOS activation pathway

REACT_12389

eNOS activation and regulation pathway

REACT_12508

Metabolism of nitric oxide pathway

REACT_111217

Metabolism pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.435850 Hs.733073

RefSeq

NM_001279356 NM_001279357 NM_001279358 NM_001279359 NM_001279360 NM_006330 XM_005251127 XM_006716417

HUGO

OMIM

CCDS

CCDS6157 CCDS64899 CCDS75738 CCDS75739

HPRD

07063

IMGT

EMBL

GenPept

RNA Seq Atlas