InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASCL2

Summary

InnateDB Protein

IDBP-22144.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASCL2

Protein Name

achaete-scute complex homolog 2 (Drosophila)

Synonyms

ASH2; bHLHa45; HASH2; MASH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000332293

InnateDB Gene

IDBG-22142 (ASCL2)

Protein Structure

UniProt Annotation

Function

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:11440538}.

Disease Associations

Tissue Specificity

Expressed specifically in the extravillous trophoblasts of the developing placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010626	negative regulation of Schwann cell proliferation
GO:0030154	cell differentiation
GO:0035019	somatic stem cell maintenance
GO:0060708	spongiotrophoblast differentiation
GO:0060712	spongiotrophoblast layer development