Version 5.4
Homo sapiens Gene: ASCL2
Summary
InnateDB Gene IDBG-22142.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASCL2
Gene Name achaete-scute complex homolog 2 (Drosophila)
Synonyms ASH2; bHLHa45; HASH2; MASH2
Species Homo sapiens
Ensembl Gene ENSG00000183734
Encoded Proteins
IDBP-22144
achaete-scute complex homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5\'-CANNTG-3\'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:2268495-2270952
Strand Reverse strand
Band p15.5
Transcripts
ENST00000331289 ENSP00000332293
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010626 negative regulation of Schwann cell proliferation
GO:0030154 cell differentiation
GO:0035019 somatic stem cell maintenance
GO:0060708 spongiotrophoblast differentiation
GO:0060712 spongiotrophoblast layer development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009248
View Gene Order
ENSBTAG00000026769
Not yet available
Cross-References
SwissProt Q99929
TrEMBL
UniProt Splice Variant
Entrez Gene 430
UniGene Hs.152475
RefSeq NM_005170
HUGO HGNC:739
OMIM 601886
CCDS CCDS7732
HPRD 03533
IMGT
EMBL AF442769 BC057801 BC136561 BC136567 S82817 U77629
GenPept AAB39362 AAB86993 AAH57801 AAI36562 AAI36568 AAL35362
RNA Seq Atlas 430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca