InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MED31

Summary

InnateDB Protein

IDBP-22474.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED31

Protein Name

mediator complex subunit 31

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000225728

InnateDB Gene

IDBG-22470 (MED31)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	87 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0010467	gene expression
GO:0048147	negative regulation of fibroblast proliferation
GO:0060173	limb development