InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SDR16C5

Summary

InnateDB Protein

IDBP-22542.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDR16C5

Protein Name

short chain dehydrogenase/reductase family 16C, member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000307607

InnateDB Gene

IDBG-22540 (SDR16C5)

Protein Structure

UniProt Annotation

Function

Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. {ECO:0000269PubMed:18926804}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in adult lung. Detected at low levels in adult brain, heart, testis, placenta, cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients. Detected in fetal kidney, skin and lung. {ECO:0000269PubMed:12372410}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004745	retinol dehydrogenase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0008152	metabolic process
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0043616	keratinocyte proliferation
GO:0050908	detection of light stimulus involved in visual perception
GO:0055114	oxidation-reduction process