InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIVA1

Summary

InnateDB Protein

IDBP-22677.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIVA1

Protein Name

SIVA1, apoptosis-inducing factor

Synonyms

CD27BP; SIVA; Siva-1; Siva-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000329447

InnateDB Gene

IDBG-22673 (SIVA1)

Protein Structure

UniProt Annotation

Function

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis. {ECO:0000269PubMed:12011449, ECO:0000269PubMed:14739602, ECO:0000269PubMed:15034012, ECO:0000269PubMed:15958577, ECO:0000269PubMed:16491128}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15034012}. Nucleus {ECO:0000269PubMed:15034012}. Note=In the nucleus, accumulates in dot-like structures.

Disease Associations

Tissue Specificity

Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0005175	CD27 receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006924	activation-induced cell death of T cells
GO:0009615	response to virus
GO:0016032	viral process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway