Version 5.4
Homo sapiens Gene: SIVA1
Summary
InnateDB Gene IDBG-22673.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIVA1
Gene Name SIVA1, apoptosis-inducing factor
Synonyms CD27BP; SIVA; Siva-1; Siva-2
Species Homo sapiens
Ensembl Gene ENSG00000184990
Encoded Proteins
IDBP-22675
SIVA1, apoptosis-inducing factor
IDBP-22677
SIVA1, apoptosis-inducing factor
IDBP-590308
SIVA1, apoptosis-inducing factor
IDBP-585811
SIVA1, apoptosis-inducing factor
IDBP-585835
SIVA1, apoptosis-inducing factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19584092
SIVA1 diminishes NFkappaB and enhances JNK activity to favour apoptosis by physically interacting with MAP3K7 (TAK1) and XIAP.
PMID 19392652
SIVA1 promotes K-48 polyubiquitination of TRAF2 and inhibits TCR-mediated activation of NF-kappaB.
Entrez Gene
Summary This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:104753100-104768494
Strand Forward strand
Band q32.33
Transcripts
ENST00000329967 ENSP00000329213
ENST00000347067 ENSP00000329447
ENST00000535554
ENST00000553810 ENSP00000451570
ENST00000553819 ENSP00000451427
ENST00000554013
ENST00000556431
ENST00000556195 ENSP00000451823
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005175 CD27 receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006924 activation-induced cell death of T cells
GO:0009615 response to virus
GO:0016032 viral process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0045087 innate immune response (InnateDB)
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000064326
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10572
UniGene Hs.112058
RefSeq NM_006427 NM_021709
HUGO HGNC:17712
OMIM 605567
CCDS CCDS9992 CCDS9993
HPRD 16124
IMGT
EMBL
GenPept
RNA Seq Atlas 10572

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca