Version 5.4
Homo sapiens Protein: RUFY3
Summary
InnateDB Protein IDBP-22685.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUFY3
Protein Name RUN and FYVE domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000226328
InnateDB Gene IDBG-22683 (RUFY3)
Protein Structure
UniProt Annotation
Function Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). {ECO:0000250}.
Subcellular Localization Cell projection {ECO:0000250}. Note=Enriched in F-actin enriched filopodia and lamellipodia of growth cones of axons and minor processes of hippocampal neurons in culture. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0050771 negative regulation of axonogenesis
Cellular Component
GO:0030175 filopodium
GO:0030426 growth cone
Protein Structure and Domains
PDB ID
InterPro IPR004012 RUN
IPR009053 Prefoldin
PFAM PF02759
PRINTS
PIRSF
SMART SM00593
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L099
PhosphoSite PhosphoSite-Q7L099
TrEMBL D6REM9
UniProt Splice Variant
Entrez Gene 22902
UniGene Hs.7972
RefSeq NP_055776
HUGO HGNC:30285
OMIM 611194
CCDS CCDS3547
HPRD 15251
IMGT
EMBL AB020678 AC009570 AF112221 AK000911 AK302637 BC051716 CH471057
GenPept AAF17208 AAH51716 BAA74894 BAG50837 BAG63879 EAX05629 EAX05630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca