InnateDB Protein
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IDBP-229047.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP5J
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Protein Name
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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
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Synonyms
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ATP5; ATP5A; ATPM; CF6; F6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000382966
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InnateDB Gene
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IDBG-1075 (ATP5J)
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Protein Structure
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Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
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Subcellular Localization |
Mitochondrion. Mitochondrion inner membrane.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
GO:0000276
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mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
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GO:0005739
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mitochondrion
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GO:0005743
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mitochondrial inner membrane
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GO:0005753
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mitochondrial proton-transporting ATP synthase complex
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PDB ID |
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InterPro |
IPR008387
ATPase, F0 complex, subunit F6, mitochondrial
IPR016349
ATPase, F0 complex, subunit F6, mitochondrial subgroup
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PFAM |
PF05511
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PRINTS |
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PIRSF |
PIRSF002455
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P18859
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PhosphoSite |
PhosphoSite-P18859
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TrEMBL |
Q6IB54
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UniProt Splice Variant |
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Entrez Gene |
522
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UniGene |
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RefSeq |
XP_005261049
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HUGO |
HGNC:847
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OMIM |
603152
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CCDS |
CCDS13574
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HPRD |
04399
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IMGT |
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EMBL |
AK311899
AL110183
AP001694
AY544129
BC001178
BT007244
CH471079
CR456950
DT217787
M37104
M73031
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GenPept |
AAA51807
AAA58630
AAH01178
AAP35908
AAT11160
BAG34840
CAB53667
CAG33231
EAX09971
EAX09973
EAX09974
EAX09975
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