InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TJP1

Summary

InnateDB Protein

IDBP-229201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TJP1

Protein Name

tight junction protein 1 (zona occludens 1)

Synonyms

ZO-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000382890

InnateDB Gene

IDBG-4684 (TJP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	100 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR000906 ZU5 domain
IPR001452 SH3 domain
IPR001478 PDZ domain
IPR005417 Zona occludens protein
IPR005418 Zona occludens protein ZO-1
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM