Version 5.4
Homo sapiens Gene: TJP1
Summary
InnateDB Gene IDBG-4684.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TJP1
Gene Name tight junction protein 1
Synonyms ZO-1
Species Homo sapiens
Ensembl Gene ENSG00000104067
Encoded Proteins
IDBP-4686
tight junction protein 1 (zona occludens 1)
IDBP-4688
tight junction protein 1 (zona occludens 1)
IDBP-229201
tight junction protein 1 (zona occludens 1)
IDBP-229203
tight junction protein 1 (zona occludens 1)
IDBP-584604
tight junction protein 1 (zona occludens 1)
IDBP-594716
tight junction protein 1 (zona occludens 1)
IDBP-602887
tight junction protein 1 (zona occludens 1)
IDBP-747688
IDBP-807741
tight junction protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:29699367-29968865
Strand Reverse strand
Band q13.1
Transcripts
ENST00000346128 ENSP00000281537
ENST00000356107 ENSP00000348416
ENST00000400011 ENSP00000382890
ENST00000400007 ENSP00000382887
ENST00000462916
ENST00000485381
ENST00000495972 ENSP00000452729
ENST00000473741
ENST00000545208 ENSP00000441202
ENST00000561307
ENST00000558447 ENSP00000453334
ENST00000579042 ENSP00000463194
ENST00000614355 ENSP00000483470
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 106 [view]
Protein-Protein 100 [view]
Protein-DNA 5 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008022 protein C-terminus binding
GO:0019904 protein domain specific binding
Biological Process
GO:0001825 blastocyst formation
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007043 cell-cell junction assembly
GO:0007605 sensory perception of sound
GO:0032496 response to lipopolysaccharide
GO:0035329 hippo signaling
GO:0042493 response to drug
GO:0043116 negative regulation of vascular permeability
GO:0045471 response to ethanol
GO:0061024 membrane organization
GO:0071000 response to magnetism
GO:0071333 cellular response to glucose stimulus
GO:1901350 cell-cell signaling involved in cell-cell junction organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005921 gap junction
GO:0005923 tight junction
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0030054 cell junction
GO:0043296 apical junction complex
GO:0045177 apical part of cell
GO:0046581 intercellular canaliculus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030516
View Gene Order
ENSBTAG00000015398
Not yet available
Pathways
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_13579
Apoptotic cleavage of cell adhesion proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_11043
c-src mediated regulation of Cx43 function and closure of gap junctions pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_11034
Regulation of gap junction activity pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa04540
Gap junction pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04520
Adherens junction pathway
hsa04530
Tight junction pathway
INOH
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7082
UniGene Hs.510833 Hs.594680 Hs.730633 Hs.740545
RefSeq NM_001301025 NM_001301026 NM_003257 NM_175610 XM_005254617 XM_005254618 XM_005254619 XM_005254620 XM_005254621 XM_006720660 XM_006720661 XM_006725554 XM_006725555 XM_006725556 XM_006725557 XM_006725558 XM_006725560
HUGO HGNC:11827
OMIM 601009
CCDS CCDS42007 CCDS45199 CCDS73702
HPRD 03002
IMGT
EMBL
GenPept
RNA Seq Atlas 7082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca