InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MDH2

Summary

InnateDB Protein

IDBP-22997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDH2

Protein Name

malate dehydrogenase 2, NAD (mitochondrial)

Synonyms

M-MDH; MDH; MGC:3559; MOR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000327070

InnateDB Gene

IDBG-22995 (MDH2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016615	malate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060	L-malate dehydrogenase activity
GO:0043621	protein self-association
GO:0044822	poly(A) RNA binding
GO:0046554	malate dehydrogenase (NADP+) activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006099	tricarboxylic acid cycle
GO:0006107	oxaloacetate metabolic process
GO:0006108	malate metabolic process
GO:0006475	internal protein amino acid acetylation
GO:0006734	NADH metabolic process
GO:0044237	cellular metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001236 Lactate/malate dehydrogenase, N-terminal
IPR001557 L-lactate/malate dehydrogenase
IPR010097 Malate dehydrogenase, type 1
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
IPR022383 Lactate/malate dehydrogenase, C-terminal

PFAM

PF00056
PF02866

PRINTS

PR00086

PIRSF

PIRSF000102

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt