Homo sapiens Gene: MDH2
Summary
InnateDB Gene IDBG-22995.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MDH2
Gene Name malate dehydrogenase 2, NAD (mitochondrial)
Synonyms M-MDH; MDH; MGC:3559; MOR1;
Species Homo sapiens
Ensembl Gene ENSG00000146701
Encoded Proteins
malate dehydrogenase 2, NAD (mitochondrial)
malate dehydrogenase 2, NAD (mitochondrial)
malate dehydrogenase 2, NAD (mitochondrial)
malate dehydrogenase 2, NAD (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. [provided by RefSeq, Jul 2008]
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:76048051-76067508
Strand Forward strand
Band q11.23
Transcripts
ENST00000315758 ENSP00000327070
ENST00000424167
ENST00000443006 ENSP00000416929
ENST00000432020 ENSP00000408649
ENST00000461263 ENSP00000475583
ENST00000461665
ENST00000490105
ENST00000492663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016615 malate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase activity
GO:0043621 protein self-association
GO:0044822 poly(A) RNA binding
GO:0046554 malate dehydrogenase (NADP+) activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006099 tricarboxylic acid cycle
GO:0006107 oxaloacetate metabolic process
GO:0006108 malate metabolic process
GO:0006475 internal protein amino acid acetylation
GO:0006734 NADH metabolic process
GO:0044237 cellular metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Metabolism of carbohydrates pathway
Citric acid cycle (TCA cycle) pathway
Gluconeogenesis pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Citrate cycle (TCA cycle) pathway
Cysteine and methionine metabolism pathway
Pyruvate metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
INOH
Citrate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520967 Hs.689470
RefSeq NM_001282403 NM_001282404 NM_005918
HUGO
OMIM
CCDS CCDS5581 CCDS64691 CCDS75622
HPRD 01099
IMGT
EMBL
GenPept
RNA Seq Atlas