InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAZL

Summary

InnateDB Protein

IDBP-230624.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAZL

Protein Name

deleted in azoospermia-like

Synonyms

DAZH; DAZL1; DAZLA; SPGYLA;

Species

Homo sapiens

Ensembl Protein

ENSP00000382373

InnateDB Gene

IDBG-21396 (DAZL)

Protein Structure

UniProt Annotation

Function

RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis specific. {ECO:0000269PubMed:8896558, ECO:0000269PubMed:8968755, ECO:0000269PubMed:8968756}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008494	translation activator activity