InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CX3CR1

Summary

InnateDB Protein

IDBP-231177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CX3CR1

Protein Name

chemokine (C-X3-C motif) receptor 1

Synonyms

CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28;

Species

Homo sapiens

Ensembl Protein

ENSP00000382166

InnateDB Gene

IDBG-26647 (CX3CR1)

Protein Structure

UniProt Annotation

Function

Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Macular degeneration, age-related, 12 (ARMD12) [MIM:613784]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed in lymphoid and neural tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0006935	chemotaxis
GO:0006968	cellular defense response
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0009611	response to wounding
GO:0016032	viral process
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR005384 Duffy antigen/chemokine receptor
IPR005387 CX3C chemokine receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR00645
PR01559
PR01562

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49238