InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CX3CR1

Summary

InnateDB Gene

IDBG-26647.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CX3CR1

Gene Name

chemokine (C-X3-C motif) receptor 1

Synonyms

CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28

Species

Homo sapiens

Ensembl Gene

ENSG00000168329

Encoded Proteins

IDBP-26649

chemokine (C-X3-C motif) receptor 1

IDBP-231177

chemokine (C-X3-C motif) receptor 1

IDBP-372819

chemokine (C-X3-C motif) receptor 1

IDBP-372823

chemokine (C-X3-C motif) receptor 1

IDBP-594301

chemokine (C-X3-C motif) receptor 1

IDBP-603931

chemokine (C-X3-C motif) receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:39263494-39281735

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000358309	ENSP00000351059
ENST00000399220	ENSP00000382166
ENST00000435290	ENSP00000394960
ENST00000412814	ENSP00000408835
ENST00000541347	ENSP00000439140
ENST00000542107	ENSP00000444928

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016495	C-X3-C chemokine receptor activity

Biological Process

GO:0002282	microglial cell activation involved in immune response
GO:0006935	chemotaxis
GO:0006968	cellular defense response
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0009611	response to wounding
GO:0016032	viral process
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0021795	cerebral cortex cell migration
GO:0030336	negative regulation of cell migration
GO:0045766	positive regulation of angiogenesis
GO:0048246	macrophage chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0032809	neuronal cell body membrane
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000052336

View Gene Order

ENSBTAG00000002923

Not yet available

Pathways

NETPATH

REACTOME

REACT_15344

Chemokine receptors bind chemokines pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.78913

RefSeq

NM_001171171 NM_001171172 NM_001171174 NM_001337

HUGO

OMIM

CCDS

CCDS43069 CCDS54571

HPRD

03277

IMGT

EMBL

GenPept

RNA Seq Atlas