Version 5.4
Homo sapiens Gene: CX3CR1
Summary
InnateDB Gene IDBG-26647.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CX3CR1
Gene Name chemokine (C-X3-C motif) receptor 1
Synonyms CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28;
Species Homo sapiens
Ensembl Gene ENSG00000168329
Encoded Proteins
IDBP-26649
chemokine (C-X3-C motif) receptor 1
IDBP-231177
chemokine (C-X3-C motif) receptor 1
IDBP-372819
chemokine (C-X3-C motif) receptor 1
IDBP-372823
chemokine (C-X3-C motif) receptor 1
IDBP-594301
chemokine (C-X3-C motif) receptor 1
IDBP-603931
chemokine (C-X3-C motif) receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:39263494-39281735
Strand Reverse strand
Band p22.2
Transcripts
ENST00000358309 ENSP00000351059
ENST00000399220 ENSP00000382166
ENST00000435290 ENSP00000394960
ENST00000412814 ENSP00000408835
ENST00000541347 ENSP00000439140
ENST00000542107 ENSP00000444928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005515 protein binding
GO:0016495 C-X3-C chemokine receptor activity
Biological Process
GO:0002282 microglial cell activation involved in immune response
GO:0006935 chemotaxis
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009611 response to wounding
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0021795 cerebral cortex cell migration
GO:0030336 negative regulation of cell migration
GO:0045766 positive regulation of angiogenesis
GO:0048246 macrophage chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0032809 neuronal cell body membrane
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000052336
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000002923
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P49238
TrEMBL C9JLM2 C9JN40
UniProt Splice Variant
Entrez Gene 1524
UniGene Hs.78913
RefSeq NM_001171171 NM_001171172 NM_001171174 NM_001337
HUGO HGNC:2558
OMIM 601470
CCDS CCDS43069 CCDS54571
HPRD
IMGT
EMBL AC092053 AK312373 AY016370 BC028078 CH471055 DA413545 EF064744 EU006531 U20350 U28934
GenPept AAA87032 AAA91783 AAH28078 AAK08627 ABK41927 ABS29268 BAG35291 EAW64576
RNA Seq Atlas 1524

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca