InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOT1L

Summary

InnateDB Protein

IDBP-232447.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOT1L

Protein Name

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000381657

InnateDB Gene

IDBG-15707 (DOT1L)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15851025}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity

Biological Process

GO:0034968	histone lysine methylation
GO:0046425	regulation of JAK-STAT cascade
GO:2000677	regulation of transcription regulatory region DNA binding

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR013110 Histone methylation DOT1
IPR021169 Histone H3-K79 methyltransferase, metazoa
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF08123

PRINTS

PIRSF

PIRSF037123

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TEK3