InnateDB Protein
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IDBP-232447.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DOT1L
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Protein Name
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DOT1-like, histone H3 methyltransferase (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381657
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InnateDB Gene
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IDBG-15707 (DOT1L)
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Protein Structure
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Function |
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15851025}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
40
[view]
|
Protein-Protein |
38
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013110
Histone methylation DOT1
IPR021169
Histone H3-K79 methyltransferase, metazoa
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF08123
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PRINTS |
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PIRSF |
PIRSF037123
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TEK3
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PhosphoSite |
PhosphoSite-Q8TEK3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84444
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UniGene |
Hs.713641
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RefSeq |
NP_115871
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HUGO |
HGNC:24948
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OMIM |
607375
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CCDS |
CCDS42460
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HPRD |
10455
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IMGT |
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EMBL |
AB058717
AC004490
AF509504
AK074120
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GenPept |
AAC08316
AAM88322
BAB47443
BAB84946
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