Version 5.4
Homo sapiens Gene: DOT1L
Summary
InnateDB Gene IDBG-15707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOT1L
Gene Name DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104885
Encoded Proteins
IDBP-232447
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
IDBP-363043
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
IDBP-363053
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
IDBP-363056
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
IDBP-810975
DOT1-like histone H3K79 methyltransferase
IDBP-810979
DOT1-like histone H3K79 methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:2164149-2232578
Strand Forward strand
Band p13.3
Transcripts
ENST00000398665 ENSP00000381657
ENST00000452696 ENSP00000404284
ENST00000457590 ENSP00000407411
ENST00000446286 ENSP00000412916
ENST00000478937 ENSP00000484015
ENST00000482433
ENST00000591498
ENST00000586024 ENSP00000476469
ENST00000608122
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
Biological Process
GO:0034968 histone lysine methylation
GO:0046425 regulation of JAK-STAT cascade
GO:2000677 regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061589
View Gene Order
ENSBTAG00000009996
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.690154 Hs.713641
RefSeq NM_032482
HUGO
OMIM
CCDS CCDS42460
HPRD 10455
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca