InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAT2

Summary

InnateDB Protein

IDBP-232899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAT2

Protein Name

linker for activation of T cells family, member 2

Synonyms

LAB; NTAL; WBSCR15; WBSCR5; WSCR5;

Species

Homo sapiens

Ensembl Protein

ENSP00000381492

InnateDB Gene

IDBG-21069 (LAT2)

Protein Structure

UniProt Annotation

Function

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269PubMed:12486104, ECO:0000269PubMed:12514734, ECO:0000269PubMed:15010370}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12486104, ECO:0000269PubMed:12514734}; Single-pass type III membrane protein {ECO:0000269PubMed:12486104, ECO:0000269PubMed:12514734}. Note=Present in lipid rafts.

Disease Associations

Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. {ECO:0000269PubMed:11003705, ECO:0000269PubMed:11124535, ECO:0000269Ref.5}.

Tissue Specificity

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level). {ECO:0000269PubMed:11124535, ECO:0000269PubMed:12486104, ECO:0000269PubMed:12514734, ECO:0000269PubMed:16160011}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042169	SH2 domain binding

Biological Process

GO:0019722	calcium-mediated signaling
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042113	B cell activation
GO:0043303	mast cell degranulation
GO:0045087	innate immune response
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0042629	mast cell granule
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome