Version 5.4
Homo sapiens Gene: LAT2
Summary
InnateDB Gene IDBG-21069.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAT2
Gene Name linker for activation of T cells family, member 2
Synonyms LAB; NTAL; WBSCR15; WBSCR5; WSCR5
Species Homo sapiens
Ensembl Gene ENSG00000086730
Encoded Proteins
IDBP-21071
linker for activation of T cells family, member 2
IDBP-21073
linker for activation of T cells family, member 2
IDBP-21075
linker for activation of T cells family, member 2
IDBP-232899
linker for activation of T cells family, member 2
IDBP-485146
linker for activation of T cells family, member 2
IDBP-480778
linker for activation of T cells family, member 2
IDBP-474918
linker for activation of T cells family, member 2
IDBP-593109
linker for activation of T cells family, member 2
IDBP-482908
linker for activation of T cells family, member 2
IDBP-812918
linker for activation of T cells family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:74199652-74229834
Strand Forward strand
Band q11.23
Transcripts
ENST00000275635 ENSP00000275635
ENST00000344995 ENSP00000344881
ENST00000361082 ENSP00000354374
ENST00000398475 ENSP00000381492
ENST00000465116 ENSP00000420549
ENST00000460943 ENSP00000420494
ENST00000491595
ENST00000475494 ENSP00000417533
ENST00000488266 ENSP00000433807
ENST00000470709 ENSP00000419150
ENST00000490586
ENST00000612664 ENSP00000483925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042169 SH2 domain binding
Biological Process
GO:0019722 calcium-mediated signaling
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042113 B cell activation
GO:0043303 mast cell degranulation
GO:0045087 innate immune response
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000040751
View Gene Order
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt Q9GZY6
TrEMBL C9JA24 C9JDY7 F8W947
UniProt Splice Variant
Entrez Gene 7462
UniGene
RefSeq XM_005250562 NM_014146 NM_032463 NM_032464
HUGO HGNC:12749
OMIM 605719
CCDS CCDS5566
HPRD 09304
IMGT
EMBL AC005081 AF045555 AF161531 AF252611 AF252612 AF252613 AF252614 AF257135 AK002099 AK092904 AK290074 AK290916 AY190023 BC001609 BC009204 CH471200
GenPept AAF29018 AAF74978 AAF91352 AAH01609 AAH09204 AAK37429 AAK37430 AAK37431 AAK37633 AAO63155 AAS07404 AAS07405 BAA92084 BAF82763 BAF83605 BAG52627 EAW69610 EAW69611 EAW69612 EAW69613
RNA Seq Atlas 7462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca