InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRHR1

Summary

InnateDB Protein

IDBP-233434.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRHR1

Protein Name

corticotropin releasing hormone receptor 1

Synonyms

CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRH-R1h; CRHR; CRHR1f; CRHR1L;

Species

Homo sapiens

Ensembl Protein

ENSP00000381333

InnateDB Gene

IDBG-55036 (CRHR1)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269PubMed:18292205, ECO:0000269PubMed:18801728, ECO:0000269PubMed:23576434, ECO:0000269PubMed:23863939}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.

Disease Associations

Tissue Specificity

Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. {ECO:0000269PubMed:8243652}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015056	corticotrophin-releasing factor receptor activity
GO:0032403	protein complex binding
GO:0042277	peptide binding
GO:0043404	corticotropin-releasing hormone receptor activity
GO:0051424	corticotropin-releasing hormone binding

Biological Process

GO:0001666	response to hypoxia
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007565	female pregnancy
GO:0007567	parturition
GO:0007613	memory
GO:0008542	visual learning
GO:0009755	hormone-mediated signaling pathway
GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0021854	hypothalamus development
GO:0030325	adrenal gland development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030855	epithelial cell differentiation
GO:0032811	negative regulation of epinephrine secretion
GO:0035641	locomotory exploration behavior
GO:0035902	response to immobilization stress
GO:0042596	fear response
GO:0043306	positive regulation of mast cell degranulation
GO:0048148	behavioral response to cocaine
GO:0048149	behavioral response to ethanol
GO:0048167	regulation of synaptic plasticity
GO:0048266	behavioral response to pain
GO:0051458	corticotropin secretion
GO:0051602	response to electrical stimulus
GO:0051867	general adaptation syndrome, behavioral process
GO:0060291	long-term synaptic potentiation
GO:0071376	cellular response to corticotropin-releasing hormone stimulus
GO:1901215	negative regulation of neuron death
GO:1901386	negative regulation of voltage-gated calcium channel activity
GO:2000252	negative regulation of feeding behavior
GO:2000852	regulation of corticosterone secretion

Cellular Component

GO:0005771	multivesicular body
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031226	intrinsic component of plasma membrane
GO:0031982	vesicle
GO:0043025	neuronal cell body
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002001 GPCR, family 2, diuretic hormone receptor
IPR003051 GPCR, family 2, corticotropin releasing factor receptor
IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01127
PR01279
PR01280

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt