Version 5.4
Homo sapiens Gene: CRHR1
Summary
InnateDB Gene IDBG-55036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRHR1
Gene Name corticotropin releasing hormone receptor 1
Synonyms CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRH-R1h; CRHR; CRHR1f; CRHR1L
Species Homo sapiens
Ensembl Gene ENSG00000120088
Encoded Proteins
IDBP-55038
corticotropin releasing hormone receptor 1
IDBP-55040
corticotropin releasing hormone receptor 1
IDBP-55042
corticotropin releasing hormone receptor 1
IDBP-55044
corticotropin releasing hormone receptor 1
IDBP-55046
corticotropin releasing hormone receptor 1
IDBP-233434
corticotropin releasing hormone receptor 1
IDBP-589536
corticotropin releasing hormone receptor 1
IDBP-763855
IDBP-761417
IDBP-763189
IDBP-761652
IDBP-813784
corticotropin releasing hormone receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45784280-45835828
Strand Forward strand
Band q21.31
Transcripts
ENST00000293493 ENSP00000293493
ENST00000339069 ENSP00000340522
ENST00000347197 ENSP00000239167
ENST00000352855 ENSP00000344068
ENST00000314537 ENSP00000326060
ENST00000398285 ENSP00000381333
ENST00000535778 ENSP00000439934
ENST00000582766
ENST00000581479
ENST00000583888 ENSP00000462553
ENST00000580955 ENSP00000463852
ENST00000580876 ENSP00000463177
ENST00000577353 ENSP00000462016
ENST00000619154 ENSP00000484545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0015056 corticotrophin-releasing factor receptor activity
GO:0032403 protein complex binding
GO:0042277 peptide binding
GO:0043404 corticotropin-releasing hormone receptor activity
GO:0051424 corticotropin-releasing hormone binding
Biological Process
GO:0001666 response to hypoxia
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0007613 memory
GO:0008542 visual learning
GO:0009755 hormone-mediated signaling pathway
GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0021854 hypothalamus development
GO:0030325 adrenal gland development
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0030855 epithelial cell differentiation
GO:0032811 negative regulation of epinephrine secretion
GO:0035641 locomotory exploration behavior
GO:0035902 response to immobilization stress
GO:0042596 fear response
GO:0043306 positive regulation of mast cell degranulation
GO:0048148 behavioral response to cocaine
GO:0048149 behavioral response to ethanol
GO:0048167 regulation of synaptic plasticity
GO:0048266 behavioral response to pain
GO:0051458 corticotropin secretion
GO:0051602 response to electrical stimulus
GO:0051867 general adaptation syndrome, behavioral process
GO:0060291 long-term synaptic potentiation
GO:0071376 cellular response to corticotropin-releasing hormone stimulus
GO:1901215 negative regulation of neuron death
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:2000252 negative regulation of feeding behavior
GO:2000852 regulation of corticosterone secretion
Cellular Component
GO:0005771 multivesicular body
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0031226 intrinsic component of plasma membrane
GO:0031982 vesicle
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018634
View Gene Order
ENSBTAG00000002749
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04730
Long-term depression pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A0A024R9X9 B3TIK8
UniProt Splice Variant
Entrez Gene 1394
UniGene
RefSeq NM_001145146 NM_001145147 NM_001145148 NM_004382
HUGO HGNC:2357
OMIM 122561
CCDS CCDS42350 CCDS45712 CCDS45713 CCDS45714
HPRD 08830
IMGT
EMBL CH471233 EU176016
GenPept ABV80233 EAW93558 EAW93560
RNA Seq Atlas 1394

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca