Homo sapiens Gene: CRHR1
Summary
InnateDB Gene IDBG-55036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRHR1
Gene Name corticotropin releasing hormone receptor 1
Synonyms CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRH-R1h; CRHR; CRHR1f; CRHR1L;
Species Homo sapiens
Ensembl Gene ENSG00000120088
Encoded Proteins
corticotropin releasing hormone receptor 1
corticotropin releasing hormone receptor 1
corticotropin releasing hormone receptor 1
corticotropin releasing hormone receptor 1
corticotropin releasing hormone receptor 1
corticotropin releasing hormone receptor 1
corticotropin releasing hormone receptor 1
corticotropin releasing hormone receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45784280-45835828
Strand Forward strand
Band q21.31
Transcripts
ENST00000293493 ENSP00000293493
ENST00000339069 ENSP00000340522
ENST00000347197 ENSP00000239167
ENST00000352855 ENSP00000344068
ENST00000314537 ENSP00000326060
ENST00000398285 ENSP00000381333
ENST00000535778 ENSP00000439934
ENST00000582766
ENST00000581479
ENST00000583888 ENSP00000462553
ENST00000580955 ENSP00000463852
ENST00000580876 ENSP00000463177
ENST00000577353 ENSP00000462016
ENST00000619154 ENSP00000484545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0015056 corticotrophin-releasing factor receptor activity
GO:0032403 protein complex binding
GO:0042277 peptide binding
GO:0043404 corticotropin-releasing hormone receptor activity
GO:0051424 corticotropin-releasing hormone binding
Biological Process
GO:0001666 response to hypoxia
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0007613 memory
GO:0008542 visual learning
GO:0009755 hormone-mediated signaling pathway
GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0021854 hypothalamus development
GO:0030325 adrenal gland development
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0030855 epithelial cell differentiation
GO:0032811 negative regulation of epinephrine secretion
GO:0035641 locomotory exploration behavior
GO:0035902 response to immobilization stress
GO:0042596 fear response
GO:0043306 positive regulation of mast cell degranulation
GO:0048148 behavioral response to cocaine
GO:0048149 behavioral response to ethanol
GO:0048167 regulation of synaptic plasticity
GO:0048266 behavioral response to pain
GO:0051458 corticotropin secretion
GO:0051602 response to electrical stimulus
GO:0051867 general adaptation syndrome, behavioral process
GO:0060291 long-term synaptic potentiation
GO:0071376 cellular response to corticotropin-releasing hormone stimulus
GO:1901215 negative regulation of neuron death
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:2000252 negative regulation of feeding behavior
GO:2000852 regulation of corticosterone secretion
Cellular Component
GO:0005771 multivesicular body
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0031226 intrinsic component of plasma membrane
GO:0031982 vesicle
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Long-term depression pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001145146 NM_001145147 NM_001145148 NM_004382
HUGO
OMIM
CCDS CCDS42350 CCDS45712 CCDS45713 CCDS45714
HPRD 08830
IMGT
EMBL
GenPept
RNA Seq Atlas