InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASGR1

Summary

InnateDB Protein

IDBP-23370.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASGR1

Protein Name

asialoglycoprotein receptor 1

Synonyms

ASGPR; ASGPR1; CLEC4H1; HL-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000269299

InnateDB Gene

IDBG-23366 (ASGR1)

Protein Structure

UniProt Annotation

Function

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Subcellular Localization

Isoform H1a: Membrane; Single-pass type II membrane protein.Isoform H1b: Secreted {ECO:0000269PubMed:20886072}.

Disease Associations

Tissue Specificity

Expressed exclusively in hepatic parenchymal cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004873	asialoglycoprotein receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding