InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRIP1

Summary

InnateDB Protein

IDBP-234054.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIP1

Protein Name

glutamate receptor interacting protein 1

Synonyms

GRIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000381098

InnateDB Gene

IDBG-45676 (GRIP1)

Protein Structure

UniProt Annotation

Function

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. {ECO:0000269PubMed:10197531}.

Subcellular Localization

Cytoplasmic vesicle {ECO:0000269PubMed:10197531}. Endoplasmic reticulum {ECO:0000269PubMed:10197531}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). {ECO:0000250}.

Disease Associations

Fraser syndrome (FRASS) [MIM:219000]: Multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects. {ECO:0000269PubMed:22510445}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	55 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0030159	receptor signaling complex scaffold activity
GO:0050681	androgen receptor binding

Biological Process

GO:0007268	synaptic transmission
GO:0008104	protein localization
GO:0030521	androgen receptor signaling pathway
GO:0035556	intracellular signal transduction
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane
GO:0055037	recycling endosome