InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPHB1

Summary

InnateDB Protein

IDBP-234058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHB1

Protein Name

EPH receptor B1

Synonyms

ELK; EPHT2; Hek6; NET;

Species

Homo sapiens

Ensembl Protein

ENSP00000381097

InnateDB Gene

IDBG-57707 (EPHB1)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. {ECO:0000269PubMed:12223469, ECO:0000269PubMed:12925710, ECO:0000269PubMed:18034775, ECO:0000269PubMed:9430661, ECO:0000269PubMed:9499402}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18034775}; Single-pass type I membrane protein {ECO:0000269PubMed:18034775}. Early endosome membrane {ECO:0000269PubMed:18034775}. Cell projection, dendrite {ECO:0000250}.

Disease Associations

Tissue Specificity

Preferentially expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021545	cranial nerve development
GO:0021631	optic nerve morphogenesis
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022008	neurogenesis
GO:0030010	establishment of cell polarity
GO:0031290	retinal ganglion cell axon guidance
GO:0031589	cell-substrate adhesion
GO:0046328	regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048593	camera-type eye morphogenesis
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051965	positive regulation of synapse assembly
GO:0060326	cell chemotaxis
GO:0060996	dendritic spine development
GO:0060997	dendritic spine morphogenesis
GO:0061351	neural precursor cell proliferation
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031901	early endosome membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM