Homo sapiens Gene: EPHB1
Summary
InnateDB Gene IDBG-57707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPHB1
Gene Name EPH receptor B1
Synonyms ELK; EPHT2; Hek6; NET;
Species Homo sapiens
Ensembl Gene ENSG00000154928
Encoded Proteins
EPH receptor B1
EPH receptor B1
EPH receptor B1
EPH receptor B1
EPH receptor B1
EPH receptor B1
EPH receptor B1
EPH receptor B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:134597801-135260467
Strand Forward strand
Band q22.2
Transcripts
ENST00000398015 ENSP00000381097
ENST00000467013
ENST00000472904
ENST00000467708
ENST00000460895 ENSP00000417435
ENST00000482618 ENSP00000420338
ENST00000488154
ENST00000497173 ENSP00000419688
ENST00000473867 ENSP00000417216
ENST00000474732 ENSP00000418352
ENST00000493838 ENSP00000419574
ENST00000488992
ENST00000617754 ENSP00000479298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008046 axon guidance receptor activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001525 angiogenesis
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411 axon guidance
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021545 cranial nerve development
GO:0021631 optic nerve morphogenesis
GO:0021952 central nervous system projection neuron axonogenesis
GO:0022008 neurogenesis
GO:0030010 establishment of cell polarity
GO:0031290 retinal ganglion cell axon guidance
GO:0031589 cell-substrate adhesion
GO:0046328 regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0048593 camera-type eye morphogenesis
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051965 positive regulation of synapse assembly
GO:0060326 cell chemotaxis
GO:0060996 dendritic spine development
GO:0060997 dendritic spine morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0031901 early endosome membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
REACTOME
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Ephrin signaling pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
EPHB forward signaling
EphrinB-EPHB pathway
Cross-References
SwissProt
TrEMBL C9J466 C9J6S4 C9JB88 C9K090 F8WDG5
UniProt Splice Variant
Entrez Gene 2047
UniGene Hs.116092
RefSeq NM_004441
HUGO HGNC:3392
OMIM 600600
CCDS CCDS46921
HPRD 02790
IMGT
EMBL AC016931 AC016951 AC063918 AC073244 AC092969 AC109912
GenPept
RNA Seq Atlas 101927568 2047