InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPHB1

Summary

InnateDB Gene

IDBG-57707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHB1

Gene Name

EPH receptor B1

Synonyms

ELK; EPHT2; Hek6; NET

Species

Homo sapiens

Ensembl Gene

ENSG00000154928

Encoded Proteins

IDBP-234058

EPH receptor B1

IDBP-479082

EPH receptor B1

IDBP-481888

EPH receptor B1

IDBP-476038

EPH receptor B1

IDBP-475998

EPH receptor B1

IDBP-475940

EPH receptor B1

IDBP-483508

EPH receptor B1

IDBP-813758

EPH receptor B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:134597801-135260467

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000398015	ENSP00000381097
ENST00000467013
ENST00000472904
ENST00000467708
ENST00000460895	ENSP00000417435
ENST00000482618	ENSP00000420338
ENST00000488154
ENST00000497173	ENSP00000419688
ENST00000473867	ENSP00000417216
ENST00000474732	ENSP00000418352
ENST00000493838	ENSP00000419574
ENST00000488992
ENST00000617754	ENSP00000479298

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021545	cranial nerve development
GO:0021631	optic nerve morphogenesis
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022008	neurogenesis
GO:0030010	establishment of cell polarity
GO:0031290	retinal ganglion cell axon guidance
GO:0031589	cell-substrate adhesion
GO:0046328	regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048593	camera-type eye morphogenesis
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051965	positive regulation of synapse assembly
GO:0060326	cell chemotaxis
GO:0060996	dendritic spine development
GO:0060997	dendritic spine morphogenesis
GO:0061351	neural precursor cell proliferation
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031901	early endosome membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome