InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGB2

Summary

InnateDB Protein

IDBP-234405.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB2

Protein Name

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

Synonyms

CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7;

Species

Homo sapiens

Ensembl Protein

ENSP00000380952

InnateDB Gene

IDBG-5590 (ITGB2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0008305	integrin complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References