InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLG4

Summary

InnateDB Protein

IDBP-23452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG4

Protein Name

discs, large homolog 4 (Drosophila)

Synonyms

PSD95; SAP-90; SAP90;

Species

Homo sapiens

Ensembl Protein

ENSP00000307471

InnateDB Gene

IDBG-23446 (DLG4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	136 [view]
Protein-Protein	133 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019903	protein phosphatase binding
GO:0030165	PDZ domain binding
GO:0031697	beta-1 adrenergic receptor binding
GO:0031748	D1 dopamine receptor binding
GO:0031812	P2Y1 nucleotide receptor binding
GO:0032403	protein complex binding
GO:0033130	acetylcholine receptor binding
GO:0035255	ionotropic glutamate receptor binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002091	negative regulation of receptor internalization
GO:0006461	protein complex assembly
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007612	learning
GO:0016188	synaptic vesicle maturation
GO:0035418	protein localization to synapse
GO:0045184	establishment of protein localization
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050806	positive regulation of synaptic transmission
GO:0060997	dendritic spine morphogenesis
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097120	receptor localization to synapse
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030666	endocytic vesicle membrane
GO:0030863	cortical cytoskeleton
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032839	dendrite cytoplasm
GO:0044224	juxtaparanode region of axon
GO:0044306	neuron projection terminus
GO:0044309	neuron spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR016313 Disks large 1
IPR019583 PDZ-associated domain of NMDA receptors
IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM