Version 5.4
Homo sapiens Protein: LSS
Summary
InnateDB Protein IDBP-234712.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSS
Protein Name lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Synonyms OSC;
Species Homo sapiens
Ensembl Protein ENSP00000380837
InnateDB Gene IDBG-6269 (LSS)
Protein Structure
UniProt Annotation
Function Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. {ECO:0000269PubMed:7639730}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:14766201, ECO:0000269PubMed:15525992}; Peripheral membrane protein {ECO:0000269PubMed:14766201, ECO:0000269PubMed:15525992}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000250 lanosterol synthase activity
GO:0003824 catalytic activity
GO:0016866 intramolecular transferase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008202 steroid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR018333 Squalene cyclase
PFAM PF00432
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48449
PhosphoSite PhosphoSite-P48449
TrEMBL
UniProt Splice Variant
Entrez Gene 4047
UniGene Hs.734274
RefSeq NP_002331
HUGO HGNC:6708
OMIM 600909
CCDS CCDS13733
HPRD 02945
IMGT
EMBL AJ239021 AJ239022 AJ239023 AJ239024 AJ239025 AJ239026 AJ239027 AJ239028 AJ239029 AJ239030 AJ239031 AK226141 AK296313 AP001468 AP001469 BC035638 CH471079 D63807 S81221 U22526 X87809
GenPept AAB36220 AAC50184 AAH35638 BAA09875 BAG59011 CAA61078 CAB42828 EAX09299 EAX09301 EAX09302 EAX09303

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca