Homo sapiens Gene: LSS
Summary
InnateDB Gene IDBG-6269.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSS
Gene Name lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Synonyms OSC;
Species Homo sapiens
Ensembl Gene ENSG00000160285
Encoded Proteins
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:46188141-46228824
Strand Reverse strand
Band q22.3
Transcripts
ENST00000356396 ENSP00000348762
ENST00000397728 ENSP00000380837
ENST00000457828 ENSP00000409191
ENST00000419093 ENSP00000410678
ENST00000450351 ENSP00000391368
ENST00000491729
ENST00000474319
ENST00000522411 ENSP00000429133
ENST00000484808
ENST00000464357
ENST00000472272
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000250 lanosterol synthase activity
GO:0003824 catalytic activity
GO:0016866 intramolecular transferase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Metabolism pathway
KEGG
Steroid biosynthesis pathway
INOH
Steroids metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL C9J315
UniProt Splice Variant
Entrez Gene 4047
UniGene Hs.596543 Hs.734274
RefSeq NM_001001438 NM_002340 NM_001145436 NM_001145437 XM_006724003
HUGO HGNC:6708
OMIM 600909
CCDS CCDS13733 CCDS46654 CCDS54489
HPRD 02945
IMGT
EMBL AP001468 AP001469
GenPept
RNA Seq Atlas 4047