Version 5.4
Homo sapiens Gene: LSS
Summary
InnateDB Gene IDBG-6269.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSS
Gene Name lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Synonyms OSC
Species Homo sapiens
Ensembl Gene ENSG00000160285
Encoded Proteins
IDBP-6271
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
IDBP-234712
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
IDBP-371572
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
IDBP-371575
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
IDBP-371582
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
IDBP-479236
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:46188141-46228824
Strand Reverse strand
Band q22.3
Transcripts
ENST00000356396 ENSP00000348762
ENST00000397728 ENSP00000380837
ENST00000457828 ENSP00000409191
ENST00000419093 ENSP00000410678
ENST00000450351 ENSP00000391368
ENST00000491729
ENST00000474319
ENST00000522411 ENSP00000429133
ENST00000484808
ENST00000464357
ENST00000472272
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000250 lanosterol synthase activity
GO:0003824 catalytic activity
GO:0016866 intramolecular transferase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033105
View Gene Order
ENSBTAG00000018936
Not yet available
Pathways
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00100
Steroid biosynthesis pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596543 Hs.734274
RefSeq NM_001001438 NM_001145436 NM_001145437 NM_002340 XM_006724003
HUGO
OMIM
CCDS CCDS13733 CCDS46654 CCDS54489
HPRD 02945
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca