InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMF

Summary

InnateDB Protein

IDBP-235077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMF

Protein Name

Bcl2 modifying factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380703

InnateDB Gene

IDBG-6070 (BMF)

Protein Structure

UniProt Annotation

Function

May play a role in apoptosis. Isoform 1 seems to be the main initiator.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. {ECO:0000269PubMed:14574334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0032464	positive regulation of protein homooligomerization
GO:0043276	anoikis
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway