Homo sapiens Gene: BMF | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-6070.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | BMF | ||||||||||||||||||||||
Gene Name | Bcl2 modifying factor | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000104081 | ||||||||||||||||||||||
Encoded Proteins |
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 15:40087890-40108892 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q15.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
TCR pathway
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REACTOME |
Activation of BMF and translocation to mitochondria pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Apoptosis pathway
Activation of BH3-only proteins pathway
Intrinsic Pathway for Apoptosis pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q96LC9 | ||||||||||||||||||||||
TrEMBL | H0YNT3 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 90427 | ||||||||||||||||||||||
UniGene | Hs.591104 Hs.618992 | ||||||||||||||||||||||
RefSeq | NM_001003940 NM_001003942 NM_001003943 NM_033503 XM_005254757 XM_005254760 XM_005254761 XM_006720729 XM_006720730 XM_006720731 XM_006720732 XM_006720733 XM_006720734 XM_006720735 | ||||||||||||||||||||||
HUGO | HGNC:24132 | ||||||||||||||||||||||
OMIM | 606266 | ||||||||||||||||||||||
CCDS | CCDS32196 CCDS10052 CCDS45223 | ||||||||||||||||||||||
HPRD | 05881 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC021755 AK024472 AY029254 AY222040 AY222041 BC060783 BC069328 BC069505 BC070043 BC104983 BC104985 | ||||||||||||||||||||||
GenPept | AAH60783 AAH69328 AAH69505 AAH70043 AAI04984 AAI04986 AAK38748 AAP22965 AAP22966 BAB15762 | ||||||||||||||||||||||
RNA Seq Atlas | 90427 | ||||||||||||||||||||||