Homo sapiens Gene: BMF
Summary
InnateDB Gene IDBG-6070.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMF
Gene Name Bcl2 modifying factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104081
Encoded Proteins
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Bcl2 modifying factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40087890-40108892
Strand Reverse strand
Band q15.1
Transcripts
ENST00000354670 ENSP00000346697
ENST00000397573 ENSP00000380703
ENST00000431415 ENSP00000396511
ENST00000561360 ENSP00000453892
ENST00000561282 ENSP00000453522
ENST00000558774 ENSP00000453913
ENST00000559701 ENSP00000453919
ENST00000557870 ENSP00000454142
ENST00000560430 ENSP00000452660
ENST00000558057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0032464 positive regulation of protein homooligomerization
GO:0043276 anoikis
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016459 myosin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Activation of BMF and translocation to mitochondria pathway
Apoptosis pathway
Activation of BH3-only proteins pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96LC9
TrEMBL H0YNT3
UniProt Splice Variant
Entrez Gene 90427
UniGene Hs.591104 Hs.618992
RefSeq NM_001003940 NM_033503 NM_001003942 NM_001003943 XM_005254757 XM_006720735 XM_005254761 XM_005254760 XM_006720733 XM_006720732 XM_006720731 XM_006720730 XM_006720729 XM_006720734
HUGO HGNC:24132
OMIM 606266
CCDS CCDS32196 CCDS10052 CCDS45223
HPRD 05881
IMGT
EMBL AC021755 AK024472 AY029254 AY222040 AY222041 BC060783 BC069328 BC069505 BC070043 BC104983 BC104985
GenPept AAH60783 AAH69328 AAH69505 AAH70043 AAI04984 AAI04986 AAK38748 AAP22965 AAP22966 BAB15762
RNA Seq Atlas 90427