InnateDB Protein
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IDBP-235202.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE2I
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Protein Name
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ubiquitin-conjugating enzyme E2I
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Synonyms
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C358B7.1; P18; UBC9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380649
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InnateDB Gene
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IDBG-8784 (UBE2I)
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Protein Structure
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Function |
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000269PubMed:11451954, ECO:0000269PubMed:15809060, ECO:0000269PubMed:17466333, ECO:0000269PubMed:19638400, ECO:0000269PubMed:19744555, ECO:0000269PubMed:20077568, ECO:0000269PubMed:8668529}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus. {ECO:0000269PubMed:8610150}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 382 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated |
Total |
382
[view]
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Protein-Protein |
380
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
20 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P63279
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PhosphoSite |
PhosphoSite-P63279
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TrEMBL |
H3BRD1
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UniProt Splice Variant |
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Entrez Gene |
7329
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UniGene |
Hs.684741
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RefSeq |
NP_003336
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HUGO |
HGNC:12485
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OMIM |
601661
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CCDS |
CCDS10433
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HPRD |
09045
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IMGT |
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EMBL |
AB208988
AC120498
AE006466
AJ002385
AL031714
BC000427
BC004429
BC051289
BT006932
CH471112
D45050
U29092
U31882
U31933
U38785
U45328
U66818
U66867
X96427
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GenPept |
AAA86662
AAB02181
AAB09410
AAC50603
AAC50715
AAC50716
AAC51361
AAH00427
AAH04429
AAH51289
AAK61274
AAP35578
BAA08091
BAD92225
CAA05359
CAA65287
CAB45853
EAW85673
EAW85676
EAW85677
EAW85678
EAW85679
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