InnateDB Protein
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IDBP-235610.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RBPMS
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Protein Name
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RNA binding protein with multiple splicing
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Synonyms
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HERMES;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380486
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InnateDB Gene
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IDBG-15727 (RBPMS)
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Protein Structure
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Function |
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. {ECO:0000269PubMed:17099224}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:17099224}. Cytoplasm {ECO:0000269PubMed:17099224}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, at various levels depending on the isoform and the tissue.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
69
[view]
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Protein-Protein |
69
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006396
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RNA processing
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GO:0010862
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positive regulation of pathway-restricted SMAD protein phosphorylation
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GO:0060391
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positive regulation of SMAD protein import into nucleus
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q93062
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PhosphoSite |
PhosphoSite-
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TrEMBL |
E5RJD7
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UniProt Splice Variant |
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Entrez Gene |
11030
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UniGene |
Hs.613171
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RefSeq |
NP_001008710
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HUGO |
HGNC:19097
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OMIM |
601558
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CCDS |
CCDS6077
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HPRD |
11870
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IMGT |
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EMBL |
AC011204
AC102945
AC109329
BC003608
CH471080
D84107
D84108
D84109
D84110
D84111
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GenPept |
AAH03608
BAA12225
BAA12226
BAA12227
BAA12228
BAA12229
EAW63451
EAW63453
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