InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLAA

Summary

InnateDB Protein

IDBP-235671.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLAA

Protein Name

phospholipase A2-activating protein

Synonyms

DOA1; PLA2P; PLAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000380460

InnateDB Gene

IDBG-54945 (PLAA)

Protein Structure

UniProt Annotation

Function

Involved in the maintenance of ubiquitin levels. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0016005	phospholipase A2 activator activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0043085	positive regulation of catalytic activity

Cellular Component

GO:0070062

extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR013535 PUL
IPR015155 PLAA family ubiquitin binding, PFU
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF08324
PF09070

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y263