Homo sapiens Protein: NOXO1
Summary
InnateDB Protein IDBP-235700.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOXO1
Protein Name NADPH oxidase organizer 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380450
InnateDB Gene IDBG-9609 (NOXO1)
Protein Structure
UniProt Annotation
Function Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269PubMed:12657628, ECO:0000269PubMed:14617635, ECO:0000269PubMed:15326186, ECO:0000269PubMed:15824103, ECO:0000269PubMed:15949904, ECO:0000269PubMed:16329988, ECO:0000269PubMed:17126813, ECO:0000269PubMed:19755710}.
Subcellular Localization Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner.
Disease Associations
Tissue Specificity Expressed in testis, small and large intestines, liver, kidney and pancreas. Isoform 3 is mainly expressed in colon. Isoform 1 is preferentially expressed in testis. {ECO:0000269PubMed:12657628, ECO:0000269PubMed:15326186, ECO:0000269PubMed:15949904}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0019899 enzyme binding
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0022617 extracellular matrix disassembly
GO:0043085 positive regulation of catalytic activity
GO:0060263 regulation of respiratory burst
Cellular Component
GO:0043020 NADPH oxidase complex
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001683 Phox homologous domain
PFAM PF00018
PF14604
PF00787
PRINTS PR00452
PIRSF
SMART SM00326
SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFA2
PhosphoSite PhosphoSite-Q8NFA2
TrEMBL
UniProt Splice Variant
Entrez Gene 124056
UniGene
RefSeq NP_751908
HUGO HGNC:19404
OMIM 611256
CCDS CCDS42101
HPRD 14834
IMGT
EMBL AB097667 AF532983 AF532984 AF532985 AF539796 AY191359 AY255768 BC015917
GenPept AAH15917 AAM97925 AAM97926 AAM97927 AAN75141 AAO38665 AAP13479 BAC76711