Homo sapiens Gene: NOXO1
Summary
InnateDB Gene IDBG-9609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOXO1
Gene Name NADPH oxidase organizer 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196408
Encoded Proteins
NADPH oxidase organizer 1
NADPH oxidase organizer 1
NADPH oxidase organizer 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1978917-1984192
Strand Reverse strand
Band p13.3
Transcripts
ENST00000354249 ENSP00000346195
ENST00000356120 ENSP00000348435
ENST00000397280 ENSP00000380450
ENST00000566005 ENSP00000456800
ENST00000569739
ENST00000567471 ENSP00000454644
ENST00000563181
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0019899 enzyme binding
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0022617 extracellular matrix disassembly
GO:0043085 positive regulation of catalytic activity
GO:0060263 regulation of respiratory burst
Cellular Component
GO:0043020 NADPH oxidase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
RAC1 signaling pathway
Cross-References
SwissProt Q8NFA2
TrEMBL
UniProt Splice Variant
Entrez Gene 124056
UniGene
RefSeq NM_001267721 NM_144603 NM_172167 NM_172168 XM_005255099
HUGO HGNC:19404
OMIM 611256
CCDS CCDS58406 CCDS10454 CCDS10455 CCDS42101
HPRD 14834
IMGT
EMBL AB097667 AF532983 AF532984 AF532985 AF539796 AY191359 AY255768 BC015917
GenPept AAH15917 AAM97925 AAM97926 AAM97927 AAN75141 AAO38665 AAP13479 BAC76711
RNA Seq Atlas 124056