Version 5.4
Homo sapiens Gene: NOXO1
Summary
InnateDB Gene IDBG-9609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOXO1
Gene Name NADPH oxidase organizer 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196408
Encoded Proteins
IDBP-9611
NADPH oxidase organizer 1
IDBP-9613
NADPH oxidase organizer 1
IDBP-235700
NADPH oxidase organizer 1
IDBP-749760
IDBP-748767
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1978917-1984192
Strand Reverse strand
Band p13.3
Transcripts
ENST00000354249 ENSP00000346195
ENST00000356120 ENSP00000348435
ENST00000397280 ENSP00000380450
ENST00000566005 ENSP00000456800
ENST00000569739
ENST00000567471 ENSP00000454644
ENST00000563181
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0019899 enzyme binding
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
Biological Process
GO:0006801 superoxide metabolic process
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0022617 extracellular matrix disassembly
GO:0043085 positive regulation of catalytic activity
GO:0060263 regulation of respiratory burst
Cellular Component
GO:0043020 NADPH oxidase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019320
View Gene Order
ENSBTAG00000020369
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001267721 NM_144603 NM_172167 NM_172168 XM_005255099
HUGO
OMIM
CCDS CCDS10454 CCDS10455 CCDS42101 CCDS58406
HPRD 14834
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca