InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF1A

Summary

InnateDB Protein

IDBP-235886.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF1A

Protein Name

tumor necrosis factor receptor superfamily, member 1A

Synonyms

CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55; TNFR60;

Species

Homo sapiens

Ensembl Protein

ENSP00000380389

InnateDB Gene

IDBG-13807 (TNFRSF1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 168 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	168 [view]
Protein-Protein	165 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding

Biological Process

GO:0006693	prostaglandin metabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0071260	cellular response to mechanical stimulus
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex
GO:0045121	membrane raft