InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FST

Summary

InnateDB Protein

IDBP-236436.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FST

Protein Name

follistatin

Synonyms

FS;

Species

Homo sapiens

Ensembl Protein

ENSP00000380151

InnateDB Gene

IDBG-20490 (FST)

Protein Structure

UniProt Annotation

Function

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. {ECO:0000269PubMed:15472207}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0048185	activin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002244	hematopoietic progenitor cell differentiation
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0051798	positive regulation of hair follicle development