InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ILK

Summary

InnateDB Protein

IDBP-236827.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ILK

Protein Name

integrin-linked kinase

Synonyms

HEL-S-28; ILK-1; ILK-2; P59; p59ILK;

Species

Homo sapiens

Ensembl Protein

ENSP00000379975

InnateDB Gene

IDBG-29381 (ILK)

Protein Structure

UniProt Annotation

Function

Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Subcellular Localization

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, myofibril, sarcomere.

Disease Associations

Tissue Specificity

Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	147 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007050	cell cycle arrest
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007569	cell aging
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0010761	fibroblast migration
GO:0014044	Schwann cell development
GO:0014912	negative regulation of smooth muscle cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0021675	nerve development
GO:0022011	myelination in peripheral nervous system
GO:0030030	cell projection organization
GO:0030335	positive regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0032288	myelin assembly
GO:0032956	regulation of actin cytoskeleton organization
GO:0034329	cell junction assembly
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043206	extracellular fibril organization
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045663	positive regulation of myoblast differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045773	positive regulation of axon extension
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048812	neuron projection morphogenesis
GO:0050772	positive regulation of axonogenesis
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051291	protein heterooligomerization
GO:0051897	positive regulation of protein kinase B signaling
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000178	negative regulation of neural precursor cell proliferation

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0030017	sarcomere
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0043034	costamere
GO:0043195	terminal bouton
GO:0043198	dendritic shaft
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016253 Integrin-linked protein kinase
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00069
PF07714
PF00023
PF13606
PF11929
PF12796

PRINTS

PR00109
PR01415

PIRSF

PIRSF000654

SMART

SM00248
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References