Homo sapiens Gene: ILK
Summary
InnateDB Gene IDBG-29381.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ILK
Gene Name integrin-linked kinase
Synonyms HEL-S-28; ILK-1; ILK-2; P59; p59ILK;
Species Homo sapiens
Ensembl Gene ENSG00000166333
Encoded Proteins
integrin-linked kinase
integrin-linked kinase
integrin-linked kinase
integrin-linked kinase
integrin-linked kinase
integrin-linked kinase
integrin-linked kinase
integrin-linked kinase
integrin-linked kinase
integrin-linked kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6603708-6610874
Strand Forward strand
Band p15.4
Transcripts
ENST00000299421 ENSP00000299421
ENST00000396751 ENSP00000379975
ENST00000420936 ENSP00000403487
ENST00000532063 ENSP00000434492
ENST00000526114 ENSP00000432617
ENST00000527121 ENSP00000436062
ENST00000528995 ENSP00000435323
ENST00000534565
ENST00000526318 ENSP00000480597
ENST00000524735
ENST00000528784
ENST00000534706
ENST00000530016
ENST00000526711 ENSP00000479932
ENST00000537806 ENSP00000439606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 149 [view]
Protein-Protein 147 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001954 positive regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007050 cell cycle arrest
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0009966 regulation of signal transduction
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010761 fibroblast migration
GO:0014044 Schwann cell development
GO:0014912 negative regulation of smooth muscle cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0021675 nerve development
GO:0022011 myelination in peripheral nervous system
GO:0030030 cell projection organization
GO:0030335 positive regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0032288 myelin assembly
GO:0032956 regulation of actin cytoskeleton organization
GO:0034329 cell junction assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042327 positive regulation of phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0043206 extracellular fibril organization
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045663 positive regulation of myoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045773 positive regulation of axon extension
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048812 neuron projection morphogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050775 positive regulation of dendrite morphogenesis
GO:0051291 protein heterooligomerization
GO:0051897 positive regulation of protein kinase B signaling
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030017 sarcomere
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0043034 costamere
GO:0043195 terminal bouton
GO:0043198 dendritic shaft
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Wnt pathway
REACTOME
Cell-Cell communication pathway
Cell junction organization pathway
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
Cell-extracellular matrix interactions pathway
KEGG
PPAR signaling pathway pathway
Focal adhesion pathway
Bacterial invasion of epithelial cells pathway
Endometrial cancer pathway
INOH
PID BIOCARTA
Pten dependent cell cycle arrest and apoptosis [Biocarta view]
PID NCI
Integrins in angiogenesis
Integrin-linked kinase signaling
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.706355
RefSeq NM_001014794 NM_001014795 NM_001278441 NM_001278442 NM_004517 XM_005252904 XM_005252905
HUGO
OMIM
CCDS CCDS60712 CCDS60713 CCDS7768
HPRD 03842
IMGT
EMBL
GenPept
RNA Seq Atlas