Homo sapiens Protein: ARL4A | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-237031.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | ARL4A | ||||||||||||||||||
Protein Name | ADP-ribosylation factor-like 4A | ||||||||||||||||||
Synonyms | ARL4; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000379897 | ||||||||||||||||||
InnateDB Gene | IDBG-8759 (ARL4A) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. {ECO:0000269PubMed:10980193, ECO:0000269PubMed:17398095}. | ||||||||||||||||||
Subcellular Localization | Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000795
Elongation factor, GTP-binding domain IPR001806 Small GTPase superfamily IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006687 Small GTPase superfamily, SAR1-type IPR006689 Small GTPase superfamily, ARF/SAR type IPR006762 Gtr1/RagA G protein IPR013684 Mitochondrial Rho-like IPR019009 Signal recognition particle receptor, beta subunit IPR020849 Small GTPase superfamily, Ras type IPR024156 Small GTPase superfamily, ARF type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00009
PF00071 PF00025 PF04670 PF08477 PF09439 |
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PRINTS |
PR00315
PR00449 PR00328 |
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PIRSF | |||||||||||||||||||
SMART |
SM00175
SM00178 SM00173 SM00177 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P40617 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P40617 | ||||||||||||||||||
TrEMBL | C9J7Q9 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 10124 | ||||||||||||||||||
UniGene | Hs.741524 | ||||||||||||||||||
RefSeq | |||||||||||||||||||
HUGO | HGNC:695 | ||||||||||||||||||
OMIM | 604786 | ||||||||||||||||||
CCDS | CCDS5359 | ||||||||||||||||||
HPRD | 11987 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC011891 AF493890 AK313233 BC001111 BC003027 CH236948 CH471073 U73960 | ||||||||||||||||||
GenPept | AAB39713 AAH01111 AAH03027 AAM12604 BAG36044 EAL24295 EAW93650 EAW93652 | ||||||||||||||||||