InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNF4G

Summary

InnateDB Protein

IDBP-237544.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNF4G

Protein Name

hepatocyte nuclear factor 4, gamma

Synonyms

NR2A2; NR2A3;

Species

Homo sapiens

Ensembl Protein

ENSP00000379701

InnateDB Gene

IDBG-25986 (HNF4G)

Protein Structure

UniProt Annotation

Function

Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}.

Disease Associations

Tissue Specificity

Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0031018	endocrine pancreas development
GO:0043401	steroid hormone mediated signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000003 Retinoid X receptor/HNF4
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00545
PR00047
PR00398
PR01282

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt