InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGM5

Summary

InnateDB Protein

IDBP-237610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGM5

Protein Name

phosphoglucomutase 5

Synonyms

PGMRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000379678

InnateDB Gene

IDBG-68955 (PGM5)

Protein Structure

UniProt Annotation

Function

Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.

Subcellular Localization

Cell junction, adherens junction {ECO:0000269PubMed:8175905}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:8175905}. Note=Adherens-type cellular junctions. Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments.

Disease Associations

Tissue Specificity

Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level). {ECO:0000269PubMed:8175905, ECO:0000269PubMed:8631316}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0016868	intramolecular transferase activity, phosphotransferases

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007155	cell adhesion

Cellular Component

GO:0001725	stress fiber
GO:0005913	cell-cell adherens junction
GO:0005914	spot adherens junction
GO:0005925	focal adhesion
GO:0009898	cytoplasmic side of plasma membrane
GO:0014704	intercalated disc
GO:0016010	dystrophin-associated glycoprotein complex
GO:0030018	Z disc
GO:0030055	cell-substrate junction
GO:0042383	sarcolemma
GO:0043034	costamere

Protein Structure and Domains

PDB ID

InterPro

IPR005841 Alpha-D-phosphohexomutase superfamily
IPR005843 Alpha-D-phosphohexomutase, C-terminal
IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I
IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II
IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III
IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III

PFAM

PF00408
PF02878
PF02879
PF02880

PRINTS

PR00509

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q15124