InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGST1

Summary

InnateDB Protein

IDBP-237981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGST1

Protein Name

microsomal glutathione S-transferase 1

Synonyms

GST12; MGST; MGST-I;

Species

Homo sapiens

Ensembl Protein

ENSP00000379513

InnateDB Gene

IDBG-21764 (MGST1)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Subcellular Localization

Microsome {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070207	protein homotrimerization
GO:0071449	cellular response to lipid hydroperoxide
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane