InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MGST1

Summary

InnateDB Gene

IDBG-21764.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGST1

Gene Name

microsomal glutathione S-transferase 1

Synonyms

GST12; MGST; MGST-I

Species

Homo sapiens

Ensembl Gene

ENSG00000008394

Encoded Proteins

IDBP-21766

microsomal glutathione S-transferase 1

IDBP-237981

microsomal glutathione S-transferase 1

IDBP-237983

microsomal glutathione S-transferase 1

IDBP-237985

microsomal glutathione S-transferase 1

IDBP-597023

microsomal glutathione S-transferase 1

IDBP-599586

microsomal glutathione S-transferase 1

IDBP-585944

microsomal glutathione S-transferase 1

IDBP-594310

microsomal glutathione S-transferase 1

IDBP-586400

microsomal glutathione S-transferase 1

IDBP-594583

microsomal glutathione S-transferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:16347142-16609259

Strand

Forward strand

Band

p12.3

Transcripts

ENST00000010404	ENSP00000010404
ENST00000359720
ENST00000396210	ENSP00000379513
ENST00000396209	ENSP00000379512
ENST00000396207	ENSP00000379510
ENST00000536371	ENSP00000442557
ENST00000534835
ENST00000543076	ENSP00000442767
ENST00000539036
ENST00000537878
ENST00000542256
ENST00000539708
ENST00000535309	ENSP00000438308
ENST00000540056	ENSP00000437988
ENST00000540126	ENSP00000442970
ENST00000538885	ENSP00000440443
ENST00000538857
ENST00000535624
ENST00000624056

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0010243	response to organonitrogen compound
GO:0032496	response to lipopolysaccharide
GO:0033327	Leydig cell differentiation
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070207	protein homotrimerization
GO:0071449	cellular response to lipid hydroperoxide
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000008540

View Gene Order

ENSBTAG00000008541

Not yet available

Pathways

NETPATH

REACTOME

REACT_6926

Glutathione conjugation pathway

REACT_228214

Aflatoxin activation and detoxification pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00480

Glutathione metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00982

Drug metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.389700 Hs.680544

RefSeq

NM_001260511 NM_001267598 NM_020300 NM_145764 NM_145791 NM_145792

HUGO

OMIM

CCDS

CCDS58209 CCDS8677

HPRD

00705

IMGT

EMBL

GenPept

RNA Seq Atlas