Homo sapiens Gene: MGST1
Summary
InnateDB Gene IDBG-21764.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGST1
Gene Name microsomal glutathione S-transferase 1
Synonyms GST12; MGST; MGST-I;
Species Homo sapiens
Ensembl Gene ENSG00000008394
Encoded Proteins
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:16347142-16609259
Strand Forward strand
Band p12.3
Transcripts
ENST00000010404 ENSP00000010404
ENST00000359720
ENST00000396210 ENSP00000379513
ENST00000396209 ENSP00000379512
ENST00000396207 ENSP00000379510
ENST00000536371 ENSP00000442557
ENST00000534835
ENST00000543076 ENSP00000442767
ENST00000539036
ENST00000537878
ENST00000542256
ENST00000539708
ENST00000535309 ENSP00000438308
ENST00000540056 ENSP00000437988
ENST00000540126 ENSP00000442970
ENST00000538885 ENSP00000440443
ENST00000538857
ENST00000535624
ENST00000624056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043295 glutathione binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0010243 response to organonitrogen compound
GO:0032496 response to lipopolysaccharide
GO:0033327 Leydig cell differentiation
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070207 protein homotrimerization
GO:0071449 cellular response to lipid hydroperoxide
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glutathione conjugation pathway
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.389700 Hs.680544
RefSeq NM_001260511 NM_001267598 NM_020300 NM_145764 NM_145791 NM_145792
HUGO
OMIM
CCDS CCDS58209 CCDS8677
HPRD 00705
IMGT
EMBL
GenPept
RNA Seq Atlas